For example, cannabidol CBD is a non-psychoactive cannabinoid that has been clinically demonstrated to have analgesic, antispasmodic, anxiolytic, antipsychotic, antinausea, and anti-rheumatoid arthritic properties. Animal and human studies have shown CBD to possess anti-convulsant properties, particularly in the treatment of epilepsy. Clinical studies also demonstrate CBD to be neuroprotective against glutamate neurotoxicity 7 i.
Additional cannabinoids possessing clinically demonstrated therapeutic properties include: cannabinol anticonvulsant 13 and anti-inflammatory 14 activity ; cannabichromine anti-inflammatory 15 and antidepressant 16 activity ; and cannabigerol anti-tumoral 17 and analgesic 18 activity. Clinical data indicate that the synergism of these compounds is likely more efficacious 25 than the administration of synthetic THC alone.
Other cannabinoid and non-cannabinoid compounds in herbal cannabis … may reduce THC-induced anxiety, cholinergic deficits, and immunosuppression. Cannabis terpenoids and flavonoids may also increase cerebral blood flow, enhance cortical activity, kill respiratory pathogens, and provide anti-inflammatory activity.
Patients prescribed Marinol frequently report that its psychoactive effects are far greater than those of natural cannabis. Once swallowed, Marinol passes from the stomach to the small intestine before being absorbed into the bloodstream. Following absorption, Marinol passes through the liver where a significant proportion of the drug is metabolized into other chemicals.
By comparison, only minute quantities of hydroxy-THC are produced when cannabis is inhaled. Vaporization is an alternative method of cannabis administration that holds distinct advantages over both smoking and oral administration. Cannabis vaporization suppresses respiratory toxins by heating cannabis to a temperature where cannabinoid vapors form typically around degrees Celsius , but below the point of combustion where noxious smoke and associated toxins i.
Each patient received 2. Efficacy was only evaluable in 88 of the volunteers. A larger study , by Tramer et al. The researchers used oral dronabinol, intramuscular levonantradol, and oral nabilone. They found that the cannabinoids were effective when treating the vomiting and nausea caused by chemotherapy.
A review of studies on THC, conducted by Grant et al. The researchers found that a 25mg dose of Marinol was better at achieving pain relief in patients with multiple sclerosis than a placebo. They also found that a 25mg dose was better at reducing chronic neuropathic pain than a placebo.
A study found that those who used Marinol consumed significantly fewer opioids than the placebo group. Finally, in , researchers published the results of a pilot study featuring Marinol. They looked into its effects on 66 patients admitted to the hospital with a traumatic injury between March and October The study found that those who used Marinol consumed significantly fewer opioids than the placebo group. The researchers also wrote that the opioid-sparing effects of Marinol were potentially greater in cannabis users.
Although the usage of Marinol is on the wane in the United States it was discontinued in Canada , it still has its proponents. Marinol does not contain the hundreds of compounds found in cannabis. Why is this important? The cannabinoids and terpenes found in marijuana likely reduce the negative effects associated with THC, such as anxiety and dizziness. In , Lester Grinspoon, Professor of Psychiatry at Harvard Medical School, said he had yet to find a patient that found Marinol more useful than natural marijuana.
He asserted that if marijuana were legal, few patients would choose Marinol. There is proof of the above assertions in the form of a study by Hazekamp et al. In contrast, Marinol provides a pre-measured dose of THC, which he believes is a much better option. Marinol provides a pre-measured dose of THC, which could be a better option for many patients.
This is despite several state studies which clearly showed that patients not only preferred natural THC but claimed it was more effective. However, unbiased analysis suggests that Marinol is, in fact, inferior to medical marijuana. When it was initially released, it had a decade-long run before a single American state, California, legalized MMJ in While its market share remained high for a long time, it has severely dwindled in recent times.
An increasing number of studies conclusively prove that medical marijuana is a vastly superior treatment to pharmaceutical drugs for dozens of conditions ranging from PTSD to chronic pain. Also, it is extremely difficult for patients to self-adjust their dosage. It is also much more effective at binding to CB1 receptors in the brain, which can trigger reactions such as seizures and psychosis. Some mesothelioma patients also claim cannabis oil , another alternative treatment extracted from marijuana, has helped strengthen their immune system to fight off diseases.
Marinol was initially developed because medical marijuana was not readily available to most cancer patients. While it is still not legal on a federal level, medical marijuana is now legal in 23 states and Washington, D.
Marinol and many other herbal remedies are available to help alleviate treatment symptoms, but always consult your doctor to find out which alternative therapy is right for you. However, as required by the new California Consumer Privacy Act CCPA , you may record your preference to view or remove your personal information by completing the form below.
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Prior results do not predict a similar outcome. For more information, visit our sponsors page. Your web browser is no longer supported by Microsoft. Update your browser for more security, speed and compatibility. If you are looking for mesothelioma support, please contact our Patient Advocates at Toll Free You should not take dronabinol capsules if you are allergic to sesame oil. Dronabinol oral solution liquid medicine contains alcohol.
You should not take dronabinol liquid if you have ever had an allergic reaction to alcohol or if you also use disulfiram Antabuse or metronidazole Flagyl. Do not take dronabinol liquid within 14 days after or 7 days before using disulfiram or metronidazole. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. HIV can be passed to your baby if you are not properly treated during pregnancy.
You should not breast-feed while using this medicine, and for at least 9 days after your last dose. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.
Dronabinol is not approved for use by anyone younger than 18 years old. Get emergency medical help if you have signs of an allergic reaction : hives, skin rash or burning; mouth sores; warmth, redness, or tingly feeling; difficult breathing; swelling of your face, lips, tongue, or throat.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Avoid driving or operating machinery until you know how this medicine will affect you.
Dizziness or severe drowsiness can cause falls or other accidents. Use Marinol Dronabinol exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow all directions on your prescription label and read all medication guides or instruction sheets.
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