Some researchers believe that reducing diet-induced inflammation may help reverse leptin resistance. Focusing on an overall healthy lifestyle is also likely to be an effective strategy.
Though there is no simple way to eliminate leptin resistance, you can make long-term lifestyle changes that may improve your quality of life. Though leptin resistance does seem reversible, it involves significant diet and lifestyle changes. Leptin resistance may be one of the main reasons people gain weight and have such a hard time losing it.
Rather, there are strong biochemical and social forces at play as well. The Western diet in particular may be a leading driver of obesity. Leptin is a hormone that plays an important role in weight regulation. This article reviews what leptin is, how it works and if supplements can help…. Are you trying to lose weight? Learn if the leptin diet might be a good fit for you.
This article lists 9 hormones that control your body weight. It also lists proven strategies to optimize their function to help you lose weight. Saying that obesity is only a matter of willpower is nonsense.
There are many factors involved, both internal and external, that affect our eating…. Your hormones underlie many basic processes in your body.
This article reviews 12 actions you can take to help your hormones function optimally. For years, researchers were hesitant to connect the two, but as study results became more clear, anecdotal reports have turned to hard science. The hormone ghrelin is often termed the "hunger hormone. For many people, one of the best parts about traveling is getting to explore the local cuisines. This article looks at 10 of the healthiest cuisines….
This is a detailed article about sugar alcohols and their health effects. They have several health benefits but can also cause digestive problems.
Phenylalanine is an amino acid that your body uses to make important molecules. This article reviews phenylalanine benefits, side effects, and sources. Health Conditions Discover Plan Connect. Share on Pinterest. In essence, leptin provides the body with an index of nutritional status. Leptin's effects on body weight are mediated through effects on hypothalamic centers that control feeding behavior and hunger, body temperature and energy expenditure.
Soon after cloning the ob gene, its cDNA was expressed as protein in E. As depicted in the graph below, weight loss resulting from administration of leptin appears to result from a combination of at least two fundamental effects:. The mechanisms by which leptin exerts its effects on metabolism are largely unknown and clearly quite complex. In contrast to dieting, which results in loss of both fat and lean mass, treatment with leptin promotes lipolysis in adipose tissue, but has no apparent effect on lean tissue.
It has long been known that starvation adversely affect reproductive function. For example, very low body fat in human females is often associated with cessation of menstrual cycles, and similar effects are seen in starving or nutritionally-deprived animals.
Also, the onset of puberty is known to correlate with body condition as well as age. Leptin concentrations are low in people and animals with low body fat, and leptin appears to be a significant regulator of reproductive function. These effects are probably due in part to the ability of leptin to enhance secretion of gonadotropin-releasing hormone from the hypothalamus, and thus luteinizing and follicle-stimulating hormones from the anterior pituitary.
One of the first demonstrations of leptin's effect on reproduction dealt with onset of puberty. Prepubertal mice treated with leptin became thin, as one would expect, but also reached reproductive maturity and began cycling significantly earlier than control mice. Additionally, some humans with inactivating mutations in the leptin receptor gene not only are obese, but fail to achieve puberty.
The amount of leptin expressed by adipocytes correlates well with the lipid content of the cells. This is similar to the way people with type 2 diabetes have unusually high levels of insulin , as their body is resistant to the effects of insulin.
The cause of leptin resistance is still unclear. There is an extremely rare condition called congenital leptin deficiency, which is a genetic condition in which the body cannot produce leptin. In the UK, there are only about four families affected by this genetic condition. Absence of leptin makes the body think it does not have any fat whatsoever and this results in uncontrolled food intake and severe childhood obesity. In addition, leptin deficiency may cause delayed puberty and poor function of the immune system.
This condition can be well treated by leptin injections, which cause dramatic weight loss. About Contact Events News. Search Search. You and Your Hormones. Students Teachers Patients Browse. Human body. Home Hormones Leptin.
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